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CAS
# 6119-70-6 QUININE SULFATE, DIHYDRATE |
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Blulux Laboratories Pvt. Ltd |
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HAZARD
IDENTIFICATION
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Route Of Entry Inds - Inhalation: YES Skin: YES Ingestion: YES
Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO
Health Hazards Acute And Chronic: ACUTE: INHAL: NO DATA AVAIL. DUST MAY CAUSE
IRRIT. SKIN: NO DATA AVAIL. QUININE IS MARKED LOC IRRITANT & ANESTH.
SENSORY NERVES ARE BRIEFLY STIMULATED THAN PARALYZED. CONCS ONLY SLIGHTLY
HIGHER THAN THOSE NEC FOR ANESTH ARE LIKELY TO CAUSE EDEMA, PAIN & REACTIVE
FIBROSIS. ANESTH MAY LAST MANY HRS/DAYS. EYES: NO DATA AVAIL. QUININE IS MARKED
LOC IRRITANT & ANESTH. INGEST: SINGLE LG DOSES MAY CAUE FOLLOWING SYMPS,
ANY ONE/GROUP OF WHICH MAY REPRESENT SYNDROME KNOWN AS "CINCHON ISM"
OR HYPERSENS RXN. HEMATOLOGIC SYMPS MAY INCL ACUTE HEMOLYSIS, THROMBOCYTOPENIC
PURPURA, AGRANULOCYTOSIS & HYPOPROTHROMBINEMIA. CNS EFTS (EFTS OF OVEREXP)
Explanation of Carcinogenicity: N/P
Signs and Symptoms of Overexposure: EFTS OF OVEREXP: HYPOTENSION & CARD
ARREST POSS. DEATHS REPORTED FROM 1.5-8.0G OF QUININE, ALTHOUGH MUCH LARGER
DOSES TOLERATED. DELIRIUM, COMA/CONVLS MAY OCCUR TERMINALLY. DEATH MAY OCCUR
W/IN FEW HRS/BE DELAYED 1-2 DAYS. PERS RECOVERING F ROM LG AMTS MAY HAVE
RESIDUAL OPTIC & AUDITORY DMG. LG DOSES (UP TO 30G) IN PREGNANT WOMEN HAVE
RSLTD IN CONGENITAL MALFORMATIONS INCL DEAFNESS RELATED TO AUDITORY NERVE
HYPOPLASIA, LIMB ANOMALITIES, VISCERAL DEFECTS & VISUAL CHGS. CHRONIC:
INHAL:NO DATA VAIL AS TO WHETHER RPTD EXPOS MAY RSLT IN "CINCHONIMS"
W/SYMPS AS DESCRIBED IN INGEST. SKIN CNTCT: MAY CAUSE DERM. (SUPDAT)
Medical Conditions Aggravated by Overexposure: N/P
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FIRST AID
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INHAL: REMOVE TO FRESH AIR IMMED. IF BRTHG STOPS, PERFORM ARTF RESP. KEEP WARM
& AT REST. TREAT SYMP & SUPPORTIVELY. GET MED ATTN IMMED. SKIN: REMOVE
CONTAM CLTHG & SHOES IMMED. WASH AFFECTED AREA W/SOAP OR MILD DETERGENT
& LG AMTS OF WATER UNTIL NO EVID OF CHEM REMAINS (APPROX 15-20 MIN). GET
MED ATTN IMMED. EYES: WASH IMMED W/LG AMTS OF WATER OR NORM SALINE, OCCASNLY
LIFTING UPPER & LOWER LIDS UNTIL NO EVID OF CHEM REMAINS (AT LEST 15-20
MIN). GET MED ATTN IMMED. INGEST: RE MOVE BY GASTRIC LAVAGE OR EMESIS. MAINTAIN
BLOOD PRESS & AIRWAY. GIVE OXYG IF RESP IS DEPRESSED. DO NOT PERFORM
GASTRIC (OTHER INFO)
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FIRE FIGHTING MEASURES
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Flash Point Text: N/P
Auto Ignition Temperature Text:
Extinguishing Media: DRY CHEM, CARBON DIOXIDE, HALON, WATER SPRAY OR STANDARD
FOAM. FOR LARGER FIRES, USE WATER SPRAY, FOG OR STANDARD FOAM. (1987 EMERGENCY
RESPONSE GUIDEBOOK, DOT P 5800.4).
Fire Fighting Procedures: USE NIOSH APPROVED SCBA AND FULL PROTECTIVE EQUIPMENT
(FP N). NO ACUT HAZARD. MOVE CONTAINER FROM FIRE AREA IF POSSIBLE. AVOID
BREATHING VAPORS OR DUSTS; KEEP UPWIND.
Unusal Fire/Explosion Hazard: NEGLIGIBLE FIRE HAZARD WHEN EXPOSED TO HEAT OR
FLAME. NFPA RATINGS (SCALE 0-4): HEALTH=3; FIRE=0; REACTIVITY=0.
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RELEASE MEASURES
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Spill Release Procedures: SWEEP UP AND PLACE IN SUITABLE (FIBERBOARD)
CONTAINERS FOR RECLAMATION OR LATER DISPOSAL.
Neutralizing Agent: N/P
Waste Disposal Methods: DISPOSAL MUST BE IN ACCORDANCE WITH FEDERAL, STATE AND
LOCAL REGULATIONS (FP N).
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HANDLING AND STORAGE
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MAY BURN BUT DOES NOT IGNITE READILY. AVOID CONTACT WITH STRONG OXIDIZERS, EXCESSIVE
HEAT, SPARKS OR OPEN FLAMES.
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EXPOSURE CONTROLS/PERSONAL PROTECTION
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Respiratory Protection: FOLLOWING RESPS RECOM BASED ON INFO FOUND IN PHYSICAL
DATA, TOX & HLTH EFTS SECTIONS. RANKED IN ORDER FROM MIN TO MAX RESP PROT.
RESP SELECTED MUST BE BASED ON CONTAM LEVELS FOUND IN WORK PLACE, MUST NOT
EXCEED WORKING LIMS OF RESP & BE NIO SH APPRVD. CHEM CARTRIDGE RESP W/FULL
FACEPIECE & ORG VAP CARTRIDGE(S) IN COMBINATION W/DUST & (OTHER INFO)
Ventilation: PROVIDE LOCAL EXHAUST OR PROCESS ENCLOSURE VENTILATION SYSTEM.
Protective Gloves: IMPERVIOUS GLOVES (FP N).
Eye Protection: ANSI APPROVED CHEMICAL WORKERS GOGGLES (FP N).
Other Equipment: EMERGENCY EYE WASH & DELUGE SHOWER MEETING ANSI DESIGN
CRITERIA (FP N). APPROP PROT (IMPERVIOUS) CLTHG & EQUIP TO PREVENT RPTD OR
PRLNGD SKIN CONTACT W/THIS SUBSTANCE.
Work Hygenic Practices: EMERGENCY EYE WASH & DELUGE SHOWER MEETING ANSI
DESIGN CRITERIA (FP N). APPROP PROT (IMPERVIOUS) CLTHG & EQUIP TO PREVENT
RPTD OR PRLNGD SKIN CONTACT W/THIS SUBSTANCE.
Supplemental Safety & Health: EFTS OF OVEREXP: EYES:NO DATA AVAIL.
INGEST:RPTD EXPOS MAY CAUSE "CINCHONISM" CHARACT BY TINNUITUS, HDCH,
VERTIGO, NAUS & DISTURBED VISION W/BILATERAL DILATED PUPILS, PALLOR OF
OPTIC DISKS, NARROWING OF RETINAL VESSELS, PAPILLEDEMA & LATE C ONSTRICTION
OF VISUAL FIELDS. IF CONTINUED, SYMPS MAY ALSO INVOLVE (OTHER INFO)
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PHYSICAL AND CHEMICAL PROPERTIES
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Boiling Point:
N/P
Melting/Freezing Point: =205.C, 401.F
Decomposition Temp:
N/P
Vapor Pressure: N/P Vapor Density: N/P
Specific Gravity: NOT AVAIL
PH: 6.2 @ SATD SOLN
Viscosity: N/P
Evaporation Rate & Reference: N/P
Solubility in Water: 0.12-0.2%
Appearance and Odor: ODORLESS, SILKY, WHITE POWDER OR FINE CRYSTALS WHICH
BECOME (TRANSPORT INFO)
Percent Volatiles by Volume: N/P
Corrosion Rate: N/P
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STABILITY AND REACTIVITY
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Stability Indicator: YES
Stability Conditions to Avoid: STABLE UNDER NORMAL TEMPERATURES AND PRESSURES.
Materials to Avoid: QUININE SULFATE: NONE KNOWN.
Hazardous Decomposition Products: THERMAL DECOMPOSITION MAY RELEASE TOXIC
OXIDES OF NITROGEN AND SULFUR.
Hazardous Polymerization Products: NO
Conditions to Avoid Polymerization: N/P
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TOXICOLOGICAL
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QUININE SULFATE, DIHYDRATE: CARCIN STATUS: NONE. POISONING MAY EFT SKIN, BLOOD
& GI, RESP, CVS & NERVOUS SYSTEMS, PARTICULARLY W/EFTS ON VISION &
HEARING. PERS W/GLUCOSE-6-PD DEFICIENCY MAY BE AT INCREASED RISK FROM EXPOS DUE
TO SUSCEPTIBI LITY TO HEMOLYSIS. CONCURRENT USE OF THIS SUBSTANCE W/OTHER
VARIOUS DRUGS MAY CAUSE ADVERSE EFTS AS NOTED. QUININE TOX MAY BE ENHANCED BY
FOODS/DRUGS THAT ALKALINIZE URINE THUS INCREASING RENAL ABSORPTION. ADDITIVE
EFT MAY OCCUR W/CENTRALL Y & PERIPHERALLY ACTING ANTICHOLINERGICS. BONE
MARROW DEPRESS ADDITIVE EFT MAY OCCUR W/MYELOSUPPRESSANTS, INCLUDING RADIA
THERAPY. ADDITIVE (TRANSPORT)
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ECOLOGICAL
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OTHER INFO: PARTICULATE FILTER. POWERED AIR-PURIFYING RESP W/TIGHT-FITTING
FACEPIECE & ORG VAP CARTRIDGE(S) IN COMBINATION W/HIGH-EFFICIENCY
PARTICULATE FILTER. TYPE 'C' SUPPLIED-AIR RESP W/FULL FACEPIECE OPERATED IN
PRESS-DEMAND OR OTHER P OS PRESS MODE OR W/FULL FACEPIECE, HELMET/HOOD OPERATED
IN CONTINUOUS-FLOW MODE. SCBA W/FULL FACEPIECE OPERATED IN PRESS-DEMAND OR
OTHER POS PRESS MODE. FIREFIGHTING & OTHER IMMED DANGEROUS TO LIFE/HEALTH
CNDTNS: SCBA W/FULL FACEPIECE OPERA TED IN PRESS-DEMAND OR OTHER POS PRESS
MODE. SUPPLIED-AIR RESP W/FULL FACEPIECE & OPERATED IN PRESS-DEMAND OR
OTHER POS PRESS MODE IN COMBINATION (TRANSPORT)
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DISPOSAL
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DISPOSAL MUST BE IN ACCORDANCE WITH FEDERAL, STATE AND LOCAL REGULATIONS (FP
N).
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TRANSPORTATION
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CONTACT Blulux Laboratories Pvt. Ltd.
COMPANY
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REGULATORY
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Federal Regulatory: Y
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OTHER
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