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CAS
# 126 - 30 - 7 NEOPENTYL GLYCOL |
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Blulux Laboratories Pvt. Ltd |
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Product
name: Neopentyl glycol
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1. Product Identification
Product:
Neopentyl glycol
Product
Use: Used as an intermediate to produce saturated polyester
resins, alkyd resins,
powder
coatings, unsaturated polyester resins, plasticizers, and synthetic lubricants.
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2. Composition / Information on Ingredients
Component
CAS Number Percent %
OSHA
hazard
category:
NEOPENTYL
GLYCOL 126-30-7 99 Hazardous
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3. Hazards Identification
Emergency
Overview:
WARNING!
•
Causes eye irritation.
•
May cause respiratory tract and skin irritation.
•
Dust from this product can form an explosive organic dust cloud.
Neopentyl
glycol
Product
name: Neopentyl glycol
MSDS
number: 4831
Product
Description
Appearance:
*REQUIRED BUT MISSING*
Potential
health effects
Routes
of exposure: Skin, eyes, inhalation, ingestion.
Immediate
effects:
Skin:
May cause skin irritation. Symptoms of exposure may include: Crusting,
scaling,
weeping
and itching of skin.
Eyes:
Causes eye irritation. Symptoms of exposure may include: Eye irritation,
burning
sensation,
pain, watering, and/or change of vision.
Inhalation:
Exposure to the heated vapor can cause temporary irritation of the
respiratory
tract.
Symptoms of exposure may include: Nasal discharge, hoarseness, coughing,
chest
pain and breathing difficulty. Nausea, headache and/or dizziness.
Ingestion:
Essentially non-toxic.
Reproductive:
No evidence of reproductive effects.
Mutagenic:
Does not show mutagenic potential in Ames test.
Target
organ effects: • Overexposure (prolonged or repeated exposure) may
cause:
Kidney
damage
Central
nervous system effects
Local
irritation at the site of exposure
Medical
conditions which may be aggravated by exposure:
Significant
exposure to this chemical may adversely affect people with acute or chronic
disease of the:
Respiratory
Tract
Kidneys
Central
nervous system
For
further information, see: Section 4 - First Aid Measures
Section
5 - Fire Fighting Measures
Section
6 - Accidental Release Measures
Section
8 - Exposure Controls/Personal Protection
Section
9 - Physical and Chemical Properties
Section
10 - Stability and Reactivity
4. First Aid Measures
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Neopentyl
glycol
Skin:
Immediately flush skin with plenty of water. Remove contaminated
clothing and
shoes.
Call a physician if irritation develops and persists. Wash clothing before
reuse.
Thoroughly clean shoes before reuse.
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes. If
easy to do,
remove
contact lenses, if worn. Get medical attention immediately.
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If
breathing is
difficult,
give oxygen. Get medical attention.
Ingestion:
If large quantities of this material are swallowed, call a physician
immediately. Do
NOT
induce vomiting unless directed to do so by a physician. Never give anything
by
mouth to an unconscious person. Get medical attention.
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5. Fire Fighting Measures
NFPA:
Health: 1 Flammability: 1 Reactivity: 0
Flammable
properties
Flash
point (test method): 98 C (208 F) (Closed Cup)
Flammable
limits in air, % by volume:
Upper:
22%
Lower:
1.4%
Auto
ignition temperature: 399 C (750 F)
Products
of combustion: Carbon Monoxide.
Extinguishing
Media: Use alcohol type aqueous film forming foam for large fires.
Use CO2 or dry
chemical
for small fires.
Fire
Fighting Instructions: Water spray should be used to cool fire-exposed
structures and vessels. Water
spray
can be used to reduce the intensity of flames and to dilute spills to a
nonflammable
mixture.
Keep personnel removed from and upwind of fire. If potential
for
exposure to vapors or products of combustion exists, wear full fire fighting
turnout
gear and NIOSH approved self-contained breathing apparatus. Oxidizing
chemicals
may accelerate the burning rate in a fire situation.
Fire
Fighting
Environmental
Concerns: Thoroughly decontaminate bunker gear and other fire-fighting
equipment before
re-use.
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6. Accidental Release Measures
Spill
or Leak Instructions See Section 8 for appropriate personal protective
equipment. Contain spill with dikes of soil or nonflammable absorbent to
minimize contaminated area. Avoid run-off into storm sewers and ditches leading
to waterways. If required, notify state and local authorities. Place leaking
containers in well-ventilated area. Clean up spills by sweeping.
Keep
unnecessary people away; isolate hazard area and deny entry. Stay upwind;
keep
out of low areas. Assess the spill situation, as the spill may not evolve large
amounts of hazardous airborne contaminants in many outdoor spill situations. It
may be advisable in some cases to simply monitor the situation until spilled
product is removed.
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7. Handling and Storage
Handling:
Use with adequate ventilation. Keep containers closed when not in use.
Avoid breathing dust. Avoid contact with eyes, skin or clothing. Wash
thoroughly with soap and water after handling. Decontaminate affected clothing
thoroughly before re-use. Destroy contaminated leather clothing.
This
product may generate a static charge. Ground/bond equipment when transferring
material to prevent static accumulation. Electrical equipment and circuits in
all storage and handling must conform to requirements of National Electric Code
(Article 500 and 501) for hazardous location. Dust from this material can form
an explosive organic dust cloud. If compressed air is used to transfer this
material, special safety design considerations and procedures must be utilized
to prevent potential fires and explosions. Avoid allowing particles to
free-fall.
Storage:
Keep all containers tightly closed when not in use. Store out of direct
sunlight and on an impermeable floor.
Do
not store with incompatible materials. See Section 10. Stability and
Reactivity.
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8. Exposure Controls / Personal Protection
Engineering
Controls: General or dilution ventilation is frequently insufficient
as the sole means of
controlling
employee exposure. Local ventilation is usually preferred.
Protective
Equipment A safety shower and eyebath should be readily available.
Skin
protection: Wear impervious clothing and gloves to prevent contact.
Butyl rubber is recommended. Other protective material may be used, depending
on the situation, if adequate degradation and permeation data is available. If
other chemicals are used in conjunction with this chemical, material selection
should be based on protection for all chemicals present.
Eye/face
protection: Wear chemical goggles when there is a reasonable chance of
eye contact.
Respiratory
protection: Based on workplace contaminant level and working limits of
the respirator, use a respirator approved by NIOSH. The following is the
minimum recommended equipment for an occupational exposure level. To estimate
an occupational exposure level see Section 3, Section 8 and Section 11. For
concentrations > 1 and < 10 times the occupational exposure level: Use
air purifying respirator with full face piece and HEPA particulate filters with
organic vapor cartridge's) or canister or a full face piece powered
air-purifying respirator fitted with HEPA particulate filters and with organic
vapor cartridge's). The air purifying element must have an end of service life
indicator, or a documented change out schedule must be established. Otherwise,
use supplied air. For concentrations more than 10 times the occupational
exposure level and less than the lower of either 100 times the occupational
exposure level or the IDLH: Use Type C full facepiece supplied-air respirator
operated in positive-pressure or continuous-flow mode.
For
concentrations > 100 times the occupational exposure level or greater than
the IDLH level or unknown concentrations (such as in emergencies): Use
self-contained breathing apparatus with full facepiece in positive-pressure
mode or Type C positive-pressure full facepiece supplied-air respirator with an
auxiliary positive-pressure self-contained breathing apparatus escape system.
For
escape: Use self-contained breathing apparatus with full facepiece or any
respirator specifically approved for escape.
NEOPENTYL
GLYCOL
126-30-7
Comments:
No exposure guidelines have been established by ACGIH or OSHA.
No
IDLH level has been established by NIOSH.
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9. Physical and Chemical Properties
Vapor
Pressure: < 0.1 mm Hg at 20 deg C
Vapor
Density (Air=1 @ 20 C): 3.6
Boiling
Point (760 mmHgA): 210 C (410 F)
Melting
Point: 124 - 130 C (255 - 266 F)
Solubility
in Water @ 20 C: 100 %
Molecular
Weight: 104.1
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10. Stability and Reactivity
Stability:
Stable.
Conditions
to Avoid: Avoid generating dust.
Incompatibility:
Keep away from sulfuric acid, phosphoric acid and other dehydrating
agents,
acetic
anhydride, strong oxidizing agents such as peroxides, oxygen, nitric acid,
perchloric
acid or chromium trioxide.
Hazardous
Combustion or Decomposition Products:
Thermal
decomposition products may include oxides of carbon.
Hazardous
Polymerization: Hazardous polymerization will not occur.
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11. Toxicological Information
Component
Toxicological Information
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12. Ecological Information
Repeated
Exposure: Neopentyl glycol was tested in rats via oral gavage at 100,
300 or 1000 mg/kg/day using the OECD Combined Repeat Dose &
Reproductive/Developmental Toxicity Screening Protocol. Male vessels. Systemic
effects were not observed. Rats were exposed for 42 consecutive days, while
females were exposed from 14 days before mating to Day 3 of lactation. The No
Observed Adverse Effect Level was 100 mg/kg/day. At 300 and 1000 mg/kg/day,
liver and kidney weights were elevated in male and female rats. At 300 and 1000
mg/kg/day, blood chemistry evaluation in males indicated increases in total
protein, total bilirubin and albumin and, at 1000 mg/kg/day, a decrease in
blood glucose was also reported. Histopathological examination of males at 1000
mg/kg/day revealed adverse effects on the kidneys, but not on the liver.
Inhalation
exposure of rats to heated vapor (4000 ppm) for 6 hrs./day for 10 days caused
transient symptoms of respiratory tract irritation and some dilation of skin
blood .
Acute
Exposure:
Oral
LD50: 3.2-12.8g/kg (rats); practically nontoxic to animals.
Inhalation
LC50: 8 hr. exposure of rats to saturated vapor (20C) caused no
deaths, but narcosis was observed. Six hour exposure of rats to heated vapor
(approximately 170 mg/l) caused respiratory tract irritation and some
mortality; practically nontoxic to animals. Exposure to heated vapor has caused
temporary irritation of the upper respiratory tract in humans.
Skin:
Slight to moderate irritation (24 hr. exposure; rabbits & guinea
pigs); practically non-toxic to animals (LD50, rabbits > lOg/kg). Not a skin
sensitizer in guinea pigs.
Eye:
Severely irritating to rabbit eyes.
Mutagenicity:
Not mutagenic in vitro (Ames Test; Chinese Hamster Lung Cell assay). No
in vivo information available.
Carcinogenicity:
No information.
Reproductive/Developmental
Effects: In the study described under Repeated Exposure, no effect on
reproduction or development was observed at dose levels up to 1000 mg/kg/day.
Ecotoxicity:
Neopentyl glycol exhibits low acute and chronic toxicity to aquatic
species.
Fish
(Oryzias latipes), 96-hr. LC50 > 1000 ppm.
Water
flea (Daphnia magna Straus), 24-hr. EC50 > 500 ppm.
Water
flea (Daphnia magna), 24-hr. EC50 > 1000 ppm.
Algae
(Scenedesmus subspicatus), 72-hr. EC50 > 500 ppm.
Bacteria
(from municipal sewage treatment plant), 24-hr. SG = 2000 ppm
Bacteria
(Pseudomonas putida), TGK = 180 ppm.
The
no effect concentration for water fleas (Daphnia magna) was greater than 1000
ppm in a 21-day chronic study.
Environmental
Fate:
Degradation:
In the modified Zahn Wellens Test (OECD Guideline 302B) for inherent
biodegradability, the following degradation information was reported: 43% at 5
days; 75% at 10 days; >95% at 15 days. Another study using the same test
system reported >90% degradation after 11 days. In tests for ready
biodegradability (e.g., OECD Guideline 301C), very little degradation has been
observed. In the most recent study conducted under GLPs, 0-1% loss was reported
after 28 days. Hydrolysis half-life in water (pH 4, 7 or 9 at 25C) was 1 year.
Bioaccumultion:
The bioconcentration factor in fish (Oryzias latipes) in a 42-day study
(OECD Guideline 305C) was 0.3 to 0.5 when the test material concentration was
10 ppm and less than 9 when the test material concentration was 1 ppm. The log
n-octanol/water partition coefficients are in the range -0.12 to -0.368. This
suggests that neopentyl glycol has low potential to bioaccumulate.
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13. Disposal Considerations
Dispose
of spilled material in accordance with state and local regulations for waste
that is non-hazardous by
Federal
definition. Note that this information applies to the material as manufactured;
processing, use, or
contamination
may make this information inappropriate, inaccurate, or incomplete.
Note
that this handling and disposal information may also apply to empty containers,
liners and rinsate. State or
local
regulations or restrictions are complex and may differ from federal
regulations. This information is intended
as
an aid to proper handling and disposal; the final responsibility for handling
and disposal is with the owner of
the
waste. See Section 9 - Physical and Chemical Properties.
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14. Transport Information
US
Department of Transportation:
Shipping
name: NEOPENTYL GLYCOL
Hazard
class: Not regulated
ICAO/IATA:
Proper
Shipping Name: NEOPENTYL GLYCOL
Hazard
Classification: Not Regulated.
IMDG:
Proper
Shipping Name: NEOPENTYL GLYCOL
Hazard
Class: Not Regulated.
Flash
point (test method): 98 C (208 F) (Closed Cup)
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15. Regulatory Information
U.S.
STATE REGULATIONS
Chemicals
associated with the product which are subject to the state right-to-know
regulations are listed along with the
applicable
state(s):
TSCA
Inventory: We certify that all components are either on the TSCA
inventory or qualify for an exemption.
Environmental
Regulations:
SARA
311:
Acute
health: Yes
Chronic
health: No
Fire:
No
Sudden
release of pressure: No
Reactive:
No
INTERNATIONAL
REGULATIONS
International
Chemical Inventory
Listed
on the chemical inventories of the following countries or qualifies for an
exemption:
AUSTRALIA,
CHINA, CANADA, EUROPE, KOREA, PHILIPPINES, JAPAN
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16. Other Information
Prepared by: BLULUX LABORATORIES (P) LTD.
For questions contact: Blulux Laboratories
Pvt. Ltd.
79/66-B, I.H.I.Complex, Industrial Area, N.I.T. Faridabad,
Haryana-121001
TEL:
:++91-129-5021360, 2444433, 2237762
FAX:++ 91129-5027762 E-MAIL: blulux@rediffmail.com
The
statements contained herein are offered for informational purposes only and are
based upon technical data that Blulux Laboratories Pvt. Ltd.believes to be
accurate. It is intended for use only by persons having the necessary technical
skills and at their own discretion and risk. Since conditions and manner of use
are outside our control, we make NO WARRANTY, EXPRESS OR IMPLIED, OF
MERCHANTABILITY, FITNESS OR OTHERWISE.
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