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CAS
# 127-19-5 N, N-DIMETHYLACETAMIDE for HPLC |
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Blulux Laboratories Pvt. Ltd |
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1. Product
Identification
Synonyms: Acetic acid, dimethylamide;
dimethylacetone amide; DMAC; acetyl dimethylamide
CAS No.: 127-19-5
Molecular Weight: 87.12
Chemical Formula: (CH3)2NCOCH3
2.
Composition/Information on Ingredients
Ingredient CAS No Percent Hazardous --------------------------------------- ------------ ------------ --------- Dimethyl Acetamide 127-19-5 99 - 100% Yes
3. Hazards
Identification
Emergency
Overview
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WARNING! HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. CAUSES IRRITATION
TO SKIN, EYES AND RESPIRATORY TRACT. COMBUSTIBLE LIQUID AND VAPOR. AFFECTS
CENTRAL NERVOUS SYSTEM AND LIVER.
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Health Rating: 3 - Severe (Life)
Flammability Rating: 2 - Moderate
Reactivity Rating: 1 - Slight
Contact Rating: 3 - Severe (Life)
Lab Protective Equip: GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD;
PROPER GLOVES; CLASS B EXTINGUISHER
Storage Color Code: Red (Flammable)
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Potential Health Effects
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Inhalation:
Causes irritation to the respiratory tract. Symptoms may include coughing,
shortness of breath. Excessive inhalation of vapor may cause symptoms that
parallel ingestion, depending upon the duration and level of the exposure.
Ingestion:
Causes irritation to the gastrointestinal tract. May cause abdominal spasm,
vomiting, sweating, weakness, and headache. Large oral doses may cause
depression, lethargy, disorientation, visual and auditory hallucinations,
perceptual distortions, delusions, emotional detachment, and kidney damage.
Skin Contact:
Causes irritation to skin. Symptoms include redness, itching, and pain.
Absorption through skin is rapid and a significant exposure hazard with
symptoms paralleling ingestion.
Eye Contact:
Causes irritation, redness, and pain.
Chronic Exposure:
Prolonged or repeated exposure may cause liver damage with yellow jaundice.
Reproductive effects from exposure have been induced in laboratory animals.
Aggravation of Pre-existing Conditions:
Persons with pre-existing liver damage may be more susceptible to the effects
of this material.
4. First
Aid Measures
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Get medical attention.
Ingestion:
Give large amounts of water to drink. Never give anything by mouth to an
unconscious person. Get medical attention.
Skin Contact:
Immediately flush skin with plenty of water for at least 15 minutes while
removing contaminated clothing and shoes. Get medical attention. Wash clothing
before reuse. Thoroughly clean shoes before reuse.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting
upper and lower eyelids occasionally. Get medical attention.
5. Fire
Fighting Measures
Fire:
Flash point: 66C (151F)
Auto ignition temperature: 490C (914F)
Flammable limits in air % by volume:
lel: 1.8; uel: 11.5
Combustible Liquid and Vapor! ( lel @ 100C ; uel @ 160C )
Explosion:
Above flash point, vapor-air mixtures are explosive within flammable limits
noted above. Vapors can flow along surfaces to distant ignition source and
flash back. Sealed containers may rupture when heated. Contact with strong
oxidizers may cause fire.
Fire Extinguishing Media:
Dry chemical, foam or carbon dioxide. Water spray may be used to keep fire
exposed containers cool. Do not use halogenated extinguishing media. Direct
stream of water can scatter and spread flames.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved
self-contained breathing apparatus with full face piece operated in the
pressure demand or other positive pressure mode.
6.
Accidental Release Measures
Ventilate
area of leak or spill. Remove all sources of ignition. Wear appropriate
personal protective equipment as specified in Section 8. Isolate hazard area.
Keep unnecessary and unprotected personnel from entering. Contain and recover
liquid when possible. Use non-sparking tools and equipment. Collect liquid in
an appropriate container or absorb with an inert material (e. g., vermiculite,
dry sand, earth), and place in a chemical waste container. Do not use combustible
materials, such as saw dust. Do not flush to sewer!
7.
Handling and Storage
Keep in a
tightly closed container, stored in a cool, dry, ventilated area. Protect
against physical damage. Isolate from any source of heat or ignition. Isolate
from incompatible substances. Containers of this material may be hazardous when
empty since they retain product residues (vapors, liquid); observe all warnings
and precautions listed for the product.
8.
Exposure Controls/Personal Protection
Airborne
Exposure Limits:
Dimethylacetamide:
-OSHA Permissible Exposure Limit (PEL): 10 ppm (TWA) skin
-ACGIH Threshold Limit Value (TLV): 10 ppm (TWA) skin, A4 - Not classifiable as
a human carcinogen.
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee
exposures below the Airborne Exposure Limits. Local exhaust ventilation is
generally preferred because it can control the emissions of the contaminant at
its source, preventing dispersion of it into the general work area. Please
refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended
Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded and engineering controls are not feasible, wear
a supplied air, full-face piece respirator, airlined hood, or full-face piece
self-contained breathing apparatus. Breathing air quality must meet the
requirements of the OSHA respiratory protection standard (29CFR1910.134).
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat, apron
or coveralls, as appropriate, to prevent skin contact. Recommended glove and
clothing material: Butyl rubber.
Eye Protection:
Use chemical safety goggles and/or a full face shield where splashing is
possible. Maintain eye wash fountain and quick-drench facilities in work area.
9.
Physical and Chemical Properties
Appearance: Clear,
colorless liquid.
Odor: Faint ammonia odor.
Solubility: Miscible in water.
Specific Gravity: 0.94
pH: No information found.
% Volatiles by volume @ 21C (70F): 100
Boiling Point: 166C (331F)
Melting Point: -20C (-4F)
Vapor Density (Air=1): 3.0
Vapor Pressure (mm Hg): 1.5 @ 20C (68F)
Evaporation Rate (BuAc=1): < 0.17
10.
Stability and Reactivity
Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
Burning may produce ammonia, carbon monoxide, carbon dioxide, nitrogen oxides.
May also produce dimethylamine.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Carbon tetrachloride, oxidizing agents, halogenated compounds, iron plus
halogenated compounds. Attacks plastic and rubber. Temperatures above 350C
(622F) cause decomposition and development of pressure in closed containers.
Conditions to Avoid:
Heat, flames, ignition sources and incompatibles.
11.
Toxicological Information
Toxicological
Data:
Dimethylacetamide: oral rat LD50: 4300 mg/kg; skin rabbit LD50: 2240 mg/kg;
inhalation rat LC50: 2475 ppm/1H; investigated as a mutagen, reproductive
effector.
Reproductive Toxicity:
Has shown some evidence of reproductive effects in laboratory animals.
--------\Cancer Lists\------------------------------------------------------ ---NTP Carcinogen--- Ingredient Known Anticipated IARC Category ------------------------------------ ----- ----------- ------------- Dimethyl Acetamide (127-19-5) No No None
12. Ecological
Information
Environmental
Fate:
When released into the soil, this material is expected to leach into
groundwater. When released into water, this material is not expected to
evaporate significantly. This material is not expected to significantly bioaccumulate.
When released into the air, this material is expected to be readily degraded by
reaction with photochemically produced hydroxyl radicals. When released into
the air, this material is expected to have a half-life of less than 1 day.
Environmental Toxicity:
No information found.
13.
Disposal Considerations
Whatever
cannot be saved for recovery or recycling should be managed in an appropriate
and approved waste disposal facility. Processing, use or contamination of this
product may change the waste management options. State and local disposal
regulations may differ from federal disposal regulations. Dispose of container
and unused contents in accordance with federal, state and local requirements.
14.
Transport Information
Not
regulated.
15. Regulatory
Information
--------\Chemical Inventory Status - Part 1\--------------------------------- Ingredient TSCA EC Japan Australia ----------------------------------------------- ---- --- ----- --------- Dimethyl Acetamide (127-19-5) Yes Yes Yes Yes --------\Chemical Inventory Status - Part 2\--------------------------------- --Canada-- Ingredient Korea DSL NDSL Phil. ----------------------------------------------- ----- --- ---- ----- Dimethyl Acetamide (127-19-5) Yes Yes No Yes --------\Federal, State & International Regulations - Part 1\---------------- -SARA 302- ------SARA 313------ Ingredient RQ TPQ List Chemical Catg. ----------------------------------------- --- ----- ---- -------------- Dimethyl Acetamide (127-19-5) No No No No --------\Federal, State & International Regulations - Part 2\---------------- -RCRA- -TSCA- Ingredient CERCLA 261.33 8(d) ----------------------------------------- ------ ------ ------ Dimethyl Acetamide (127-19-5) No No Yes Chemical Weapons Convention: No TSCA 12(b): No CDTA: NoSARA 311/312: Acute: Yes Chronic: Yes Fire: Yes Pressure: NoReactivity: No (Pure / Liquid)
Australian
Hazchem Code: None allocated.
Poison Schedule: None allocated.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled
Products Regulations (CPR) and the MSDS contains all of the information
required by the CPR.
16. Other
Information
NFPA
Ratings: Health: 2 Flammability: 2 Reactivity: 0
Label Hazard Warning:
WARNING! HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. CAUSES
IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. COMBUSTIBLE LIQUID AND VAPOR.
AFFECTS CENTRAL NERVOUS SYSTEM AND LIVER.
Label Precautions:
Avoid breathing vapor.
Avoid contact with eyes, skin and clothing.
Keep container closed.
Use only with adequate ventilation.
Wash thoroughly after handling.
Keep away from heat and flame.
Label First Aid:
In case of contact, immediately flush eyes or skin with plenty of water for at
least 15 minutes while removing contaminated clothing and shoes. Wash clothing
before reuse. If inhaled, remove to fresh air. If not breathing, give
artificial respiration. If breathing is difficult, give oxygen. If swallowed,
give large amounts of water to drink. Never give anything by mouth to an
unconscious person. In all cases, get medical attention.
Product Use:
Laboratory Reagent.
Disclaimer:
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Blulux Laboratories Pvt. Ltd. provides the information contained herein in good
faith but makes no representation as to its comprehensiveness or accuracy. This
document is intended only as a guide to the appropriate precautionary handling
of the material by a properly trained person using this product. Individuals
receiving the information must exercise their independent judgment in
determining its appropriateness for a particular purpose. Blulux Laboratories
Pvt. Ltd. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED,
INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A
PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE
PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, Blulux laboratories (p) Ltd. WILL NOT BE RESPONSIBLE FOR
DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
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