CAS # 75-05-8 ACETONITRILE (METHYL CYANIDE) LR
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Blulux Laboratories Pvt. Ltd |
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HAZARD
IDENTIFICATION
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Route Of Entry Inds - Inhalation: YES Skin: YES Ingestion: YES
Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO
Health Hazards Acute And Chronic: ACUTE EFFECTS: HARMFUL IF SWALLOWED, INHALED
OR ABSORBED THROUGH SKIN. VAPOR OR MISTS IS IRRITATING TO THE EYES, MUCOUS
MEMBRANES AND UPPER RESPIRATORY TRACT. CAUSES SKIN IRRITATION. ACETONITRILE IS
METABOLIZED IN THE LIVER TO WATER, FORMIC ACID AND HYDROGEN CYANIDE. THE
CYANIDE IS FURTHER METABOLIZED TO THIOCYANATE. THE ONSET OF SYMPTOMS IS
GENERALLY DELAYED PENDING CONVERSION TO CYANIDE. ADVERSE EFFECTS MAY INCLUDE
NAUSEA, VOMITING, DIARRHEA, HEADACHE, DIZZINESS, RASHES AND CYANOSIS. OTHER
SYMPTOMS INCLUDE MENTAL EXCITEMENT OR DEPRESSION, DROWSINESS, IMPAIRED
PERCEPTION, INCOORDINATION, STUPOR, (EFFECTS OF OVEREXPOSURE)
Explanation of
Carcinogenicity:
N/P
Signs and Symptoms of Overexposure: HEALTH EFFECTS: COMA AND DEATH. TARGET
ORGANS: CENTRAL NERVOUS SYSTEM. LIVER, KIDNEYS. BLOOD, LUNGS. ALSO, SEE
TOXICOLOGICAL INFORMATION.
Medical Conditions Aggravated by
Overexposure:
N/P
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FIRST AID
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SKIN: FLUSH SKIN WITH WATER. EYES: CONTAMINATION OF EYES SHOULD BE TREATED BY
IMMEDIATE AND PROLONGED IRRIGATION WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST
15 MINUTES. INHALATION: IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE
ARTIF ICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN. INGESTION: IF
SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL A
PHYSICIAN. REMOVE AND WASH CONTAMINATED CLOTHING PROMPTLY. DISCARD CONTAMINATED
SHOES.
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FIRE FIGHTING MEASURES
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Flash Point: KEEP TIGHTLY CLOSED. KEEP AWAY FROM HEAT, SPRAKS AND OPEN FLAME.
STORE IN A COOL, DRY PLACE.
Auto Ignition
Temperature:
=522.8C, 973.F
Lower
Limits:
4.4%
Upper
Limits:
16%
Extinguishing Media: CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
WATER MAY BE EFFECTIVE FOR COOLING, BUT MAY NOT EFFECT EXTINGUISHMENT.
Fire Fighting Procedures: USE NIOSH APPROVED SCBA AND FULL PROTECTIVE EQUIPMENT
(FP N).
Unusal Fire/Explosion Hazard: EXTREMELY FLAMMABLE. VAPOR MAY TRAVEL
CONSIDERABLE DISTANCE TO SOURCE OF IGNITION AND FLASH BACK. CONTAINER EXPLOSION
MAY OCCUR UNDER FIRE CONDITIONS. EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
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RELEASE MEASURES
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Spill Release Procedures: EVACUATE AREA. SHUT OFF ALL SOURCES OF IGNITION. WEAR
NIOSH APPROVED SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
RUBBER GLOVES. COVER WITH AN ACTIVATED CARBON ABSORBENT. TAKE UP AND PLACE IN
CLOSED CONTAINERS. TRANSPORT OUTDO ORS. VENTILATE AREA AND WASH SPILL SITE
AFTER MATERIAL PICKUP IS COMPLETE.
Neutralizing Agent:
N/P
Waste Disposal Methods: BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER BUT EXERT EXTRA CARE IN IGNITING AS THIS MATERIAL IS
HIGHLY FLAMMABLE. OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL
REGULATIONS.
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HANDLING AND STORAGE
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KEEP TIGHTLY CLOSED. KEEP AWAY FROM HEAT, SPRAKS AND OPEN FLAME. STORE IN A COOL,
DRY PLACE.
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EXPOSURE CONTROLS/PERSONAL PROTECTION
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Respiratory Protection: WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation: USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves: CHEMICAL-RESISTANT GLOVES.
Eye Protection: ANSI APPROVED CHEMICAL WORKERS GOGGLES (FP N).
Other Equipment: ANSI APPROVED EYE WASH AND DELUGE SHOWER (FP N). WEAR OTHER PROTECTIVE
CLOTHING.
Work Hygenic Practices: ANSI APPROVED EYE WASH AND DELUGE SHOWER (FP N). WEAR
OTHER PROTECTIVE CLOTHING.
Supplemental Safety & Health: TOXICOLOGICAL INFO: LD50: 4480 MG/KG 85GMAT
-, 16,1982. IVN-MOUSE LD50: 612 MG/KG 85GMAT -, 16,1982. ORAL-CAT LD50: 200
MG/KG ZAARAM 19,225,1969. INHAL-CAT LD50: 18 GM/M3 85GMAT -,16,1982. ORL-RABBIT
DL50: 50 MG/KG ZAARAM 19,225,1969. INHAL -RABBIT LC50: 2828 PPM/4H JOCMA7
1,634,1959. SKIN-RABBIT LD50: (OTHER INFO)
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PHYSICAL AND CHEMICAL PROPERTIES
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Boiling
Point:
>81.C, 177.8F ,81-82C
Melting/Freezing
Point:
= -48.C, -54.4F
Decomposition
Temp:
N/P
Vapor
Pressure:
72.8 MM 20C
Vapor
Density:
1.41
Specific
Gravity:
0.786
PH:
N/P
Viscosity:
N/P
Evaporation Rate & Reference: N/P
Solubility in
Water:
N/P
Appearance and
Odor:
COLORLESS LIQUID.
Percent Volatiles by Volume: N/P
Corrosion
Rate:
N/P
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STABILITY AND REACTIVITY
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Stability
Indicator:
YES
Stability Conditions to Avoid: N/P
Materials to Avoid: ACIDS, BASES, OXIDIZING AGENTS, REDUCING AGENTS, ALKALI
METALS.
Hazardous Decomposition Products: THERMAL DECOMPOSITION MAY PRODUCE CARBON
MONOXIDE, CARBON DIOXIDE AND NITROGEN OXIDES. HYDROGEN CYANIDE.
Hazardous Polymerization
Products: NO
Conditions to Avoid
Polymerization:
N/P
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TOXICOLOGICAL
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TO THE BEST OF OUR KNOWLEDGE, CHEM, PHYSICAL & TOXICOLOGICAL PROPERTIES
HAVE NOT BEEN THOROUGHLY INVESTIGATED. RTECS #: AL7700000 ACETONITRILE. IRRIT
DATA - SKIN-RBT 500 MG OPEN MILD UCDS 3/18/1965. TOX DATA - ORAL-RAT LD50: 2460
MG/KG UCD S 3/18/1965. INHAL-RAT LC50: 7551 PPM/8H JOCMA7 1,634,1959. IPR-RAT
LD50: 850 MG/KG JOCMA7 1,634,1959. SCU-RAT LD50: 3500 MG/KG 85GMAT -, 16,1982.
IVN-RAT LD50: 1680 MG/KG JOCMA7 1,634,1959. PAR-RAT LD50: 1100 MG/KG 85GMAT -,
16,1982. ORL- MOUSE LD50: 269 MG/KG ARTODN 55,47,1984. INHAL-MOUSE LC50: 2693
PPM/1H CTOXAO 18,991,1981. IPR-MOUSE LD50: 175 MG/KG TXAPA9 59,589,1981.
SCU-MOUSE (SUPDAT)
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ECOLOGICAL
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DATA NOT YET AVAILABLE. OTHER INFO: (MUSCULOSKELETAL SYSTEM). NUTRITIONAL &
GROSS METABOLIC (CHANGES IN: METABOLIC ACIDOSIS). TUMORIGENIC (EQUIVOCAL
TUMORIGENIC AGENT BY RTECS CRITERIA). ONLY SELECTED REGISTRY OF TOX EFTS OF
CHEM SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFO. FEDERAL REG INFO: 40 PPM (70 MG/M3) CFRGBR 29,1910.1000,1994.
OSHA PEL (CONSTRUC): 8H TWA 40 PPM (70 MG/M3) CFRGBR 29,1926.55,1994. OSHA PEL
(SHIPYARD): 8H TWA 40 PPM (70 MG/M3) CFRGBR 29, 1915.1000,1993. OSHA PEL (FED
CONT): 8H TWA 40 PPM (70 MG/M3) CFRGBR 41,50-204.50,1994. (TRANSPORT INFO)
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DISPOSAL
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BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER BUT
EXERT EXTRA CARE IN IGNITING AS THIS MATERIAL IS HIGHLY FLAMMABLE. OBSERVE ALL
FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
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